NEW HORIZONS IN TOXICITY PREDICTION

 

Sponsored by: LHASA Limited:

Cambridge University, December 8 -9, 2008

 

Session Chairs:

Professor Robert Glen, Unilever Center for Molecular Informatics

Dr Alan Wilson, Lexicon Genetics Incorporated

Dr David Hawkins, Lhasa Limited Board of Directors

 

DAY ONE:

 

9:30 am Welcome and Opening Remarks
Dr David Hawkins & Professor Robert Glen (Chair)

 

Session 1: Current Approaches for Toxicity Prediction

 

        Current Status of Toxicity Prediction

        What is currently available?

        How are these tools being used by Regulators,   Industry & Academia ?

        Unmet needs?

9:45 am Opening Remarks

Dr David Hawkins (Chair)

 

9:50 am Pharmaceutical Regulatory Perspective [Abstract]
Dr Edwin J. Matthews, Food & Drug Administration

 

10:25 am In Silico Tools & Guidance developed by the European Chemicals Bureau [Abstract]
Dr Andrew Worth, European Chemicals Bureau

 

11:00 am Break

 

11:30 am Modelling and informatics support for safety an metabolism studies in early drug discovery projects [Abstract]

Dr Scott Boyer, Astra Zeneca

 

12:05 am Recent Developments in Toxico-Cheminformatics:                 Supporting a New Paradigm for Predictive Toxicology [Abstract]

Dr Ann Richard, US Environmental Protection Agency

 

12:40 pm Lunch

 

Session 2: Strengths and Limitations of Current Toxicity Prediction Systems

 

        How do different approaches compare (QSAR,   Knowledge-Based, Neural Networks)

        Pros and Cons of different systems

        Toxicity databases and tool boxes

 

2:00 pm Opening Remarks

Professor Robert Glen (Chair)

 

2:10 pm The Role of Predictive Data Mining in Understanding Toxicity [Abstract]

Professor Chihae Yang, Leadscope Inc.

 

2:45 pm Consensus QSAR Models [Abstract]

Dr Mark Cronin, Liverpool John Moores University

 

3:20 pm Break

 

3:55 pm QSAR Approaches, Models & Statistics Relating to Toxicity Prediction [Abstract]

Professor Douglas Hawkins, University of Minnesota

 

4:30 pm Knowledge-Based Approaches

Dr Nigel Greene, Pfizer

 

5:05 pm Models and Databases for Genetic/Carcinogenic Toxicity

Aldo Benigni, National Institute of Health, Italy

 

5:40 pm- End -

 

7.30pm Symposium Dinner: Peterhouse: College Campus

 

DAY TWO:

 

Session 3 Emerging Areas and Technologies in Toxicity Prediction

 

       

8:30 am Opening Remarks

Dr Alan Wilson (Chair)

 

8:40 am Use of Biosimulation and Toxicogenomics to Predict the Efficacy of Antiatherogenic Therapies, Cardiovascular Toxicity and Outcomes [Abstract]

Dr Héctor De León, Entelos

 

9:15 am Emerging Areas in Toxicity Prediction: NIHS Perspective [Abstract]

Dr Akihiko Hirose, National Institute of Health Sciences,Japan

 

9:50 am Coffee Break

 

10:20am Consumer Products Industries Perspective [Abstract]

Dr Cameron MacKay, Unilever - Safety & Environmental Assurance Centre

 

10:55 am Challenges In Predicting Metabolism & Toxicity with Known & Abstract Targets [Abstract]

Dr Fred Guengerich, Vanderbilt University

 

11:30 am Panel Discussion: Future Needs and Challenges*

 

        Identification of Gaps, Future Needs and   Challenges

        Increasing application of in silico modeling

        Barriers to implementation

 

1:00 pm Closing Remarks & End of Conference

This event precedes the Lhasa Limited European ICGM, which will also be hosted by the University of Cambridge and provides an opportunity to meet Lhasa Limited scientists and members of the Sales team, learn about Lhasa Limited's software and services, and see demonstrations of our programs. Click here for more information.